Search results for "Genetic evolution"
showing 7 items of 7 documents
Hepatitis C virus early kinetics and resistance-associated substitution dynamics during antiviral therapy with direct-acting antivirals
2018
The emergence of resistance-associated substitutions (RASs) can compromise the high efficacy of direct-acting antivirals (DAAs). Little is known about RASs selection at very early time points during DAA treatment. Therefore, we analyzed the potential emergence of RASs immediately after therapy initiation. Samples of 71 patients treated with different DAAs were collected at baseline, during therapy (hours 4 and 8; days 1-7; weeks 2-4) or until target not detected. HCV-RNA levels were determined by qPCR, and RASs were detected by deep sequencing. Sixty-three (89%) patients achieved a sustained virological response (SVR), 7 (10%) relapsed, and 1 (1%) experienced a breakthrough. Almost all non-…
Fracture stratigraphy and oil first migration in Triassic shales, Favignana Island, western Sicily, Italy
2021
This study aims at evaluating the control exerted by fracture stratigraphy and diagenetic processes on oil first migration through an outcropping, mixed carbonate-siliciclastic succession. The present work included results of sedimentological, paleontological, mineralogical, petrographic, structural, and microstructural analyses carried out on organic-rich shales exposed at the Favignana Island of Sicily, Italy. The analyses focus on Upper Triassic yellowish siltstones and greyish laminated dolomitic limestones, which form a 10's of m-thick succession exposed along the westernmost portion of the Sicilian fold-and-thrust belt. The studied succession deposited in a coastal lagoon associated t…
The evolutionary history of the rediscovered Austrian population of the giant centipede Scolopendra cingulata Latreille 1829 (Chilopoda, Scolopendrom…
2014
The thermophilous giant centipede Scolopendra cingulata is a voracious terrestrial predator, which uses its modified first leg pair and potent venom to capture prey. The highly variable species is the most common of the genus in Europe, occurring from Portugal in the west to Iran in the east. The northernmost occurrences are in Hungary and Romania, where it abides in small isolated fringe populations. We report the rediscovery of an isolated Austrian population of Scolopendra cingulata with the first explicit specimen records for more than 80 years and provide insights into the evolutionary history of the northernmost populations utilizing fragments of two mitochondrial genes, COI and 16S, …
Dynamic Community Discovery Method Based on Phylogenetic Planted Partition in Temporal Networks
2022
As most of the community discovery methods are researched by static thought, some community discovery algorithms cannot represent the whole dynamic network change process efficiently. This paper proposes a novel dynamic community discovery method (Phylogenetic Planted Partition Model, PPPM) for phylogenetic evolution. Firstly, the time dimension is introduced into the typical migration partition model, and all states are treated as variables, and the observation equation is constructed. Secondly, this paper takes the observation equation of the whole dynamic social network as the constraint between variables and the error function. Then, the quadratic form of the error function is minimized…
Genetic characterisation of CSN2 gene in Girgentana goat breed
2014
Among calcium sensitive caseins, β-casein is the most abundant in goat milk, representing up to 50% of total casein content. The goat β-casein locus has been widely investigated and at least ten alleles have been identified in different goat breeds. The aim of this work was to investigate the polymorphisms of β-casein gene in Girgentana dairy goat breed in order to assess the genotype distribution and evaluate how frequencies have changed during the last 10 years, as genotype is known to influence technological and nutritional milk properties. Sequencing analysis and alignment of the obtained sequences of β-casein exon 7, showed the presence of C, C1, and A strong alleles, and 0' null allel…
Molecular evolutionary analysis of type-1 human astroviruses identifies putative sites under selection pressure on the capsid protein
2017
Human astroviruses (HAstV) are important enteric pathogens that can be classified into eight sero/genotypes (HAstV-1 to -8). Although the various HAstV types show global spread, type-1 strains tend to be predominant. Molecular analysis of the genomic region encoding the capsid protein (ORF2) has revealed discrete sequence variation, with different lineages within each HAstV type and at least three major lineages have been identified within HAstV-1. Longitudinal epidemiological surveillance has revealed temporal shift of the various HAstV-1 lineages. Metadata analysis of HAstV-1 sequences available in the databases also revealed temporal shifts of the circulation of HAstV-1 lineages, suggest…